Current Issue : July - September Volume : 2015 Issue Number : 3 Articles : 5 Articles
To the date, large number of drugs having better efficiency in clinical application but have restricted its use due to poor water solubility. Nanocrystals have the potential to overcome the issue. Drug nanocrystals are crystals with a size in the nanometer range (mean diameter < 100 nm). Tadalafil is a BCS class II drug, which is an impotence agent. It is used for the treatment of erectile dysfunction and is a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5) which is selective inhibitor. In this present work, a nanocrystals of Tadalafil (TDL) was formulated by precipitation method using probe sonicator. It was formulated using stabilizer poloxamer 188 with DMSO as solvent and at proper dilution of drug solution with water and obtained dried product by freeze-drying. The significant enhancement solubility and dissolution rate was observed. The characterization of formulation done by differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), X-Ray powder diffraction (XRPD), scanning electronic microscopy (SEM) and particle size analysis....
The major objective of this study was to prepare and evaluate once daily sustained release matrix pellets formulation of levofloxacin by using extrusion-spheronization technique. The sustained release matrix pellets of levofloxacin were prepared by industrially applied extrusion spheronization technique. The different formulations were prepared using EUDRAGIT L and EUDRAGIT S as hydrophilic or hydrophobic matrix polymer MCC PH101 as a spheronization aid. The prepared pellets were evaluated for parameters like flow properties, morphological characteristics, drug content and in-vitro drug release study in pH 6.8 phosphate buffer experimental design technique was used to select optimized formulation releasing drug for 12 hr. The levofloxacin SR matrix pellets composed of EUDRAGIT L 6% and EUDRAGIT S 6% was selected as optimized. The evaluated parameters of optimised batch were found within the limits. Drug release of optimized batch (F6) at 2 hr was found to be less than 15% (15.67% and at 12 hr more than 90% (99.70%). The results from this study showed that combination of EUDRAGIT L and EUDRAGIT S as hydrophilic matrix polymer MCC PH101 as a spheronization aid was effective and useful for sustaining the levofloxacin release. And hence extrusion spheronization technique can be promising approach for the preparation of pellets which assure its applicability for large scale manufacturing....
Metoprolol Succinate is a beta blocker widely used for the treatment of hypertension. Its short biological half-life (3-7 Hrs), BCS Class-I and thus frequent administration (usually 3-4 times a day) makes it a suitable candidate for controlled release drug delivery system. So, attempt was to develop a once daily controlled release osmotic drug delivery system. This may offer significant patient compliance by providing enhanced efficacy and reduced side effects and may also reduce the number of daily doses compared to conventional therapies. A 32 factorial design was employed to optimize the amount of osmopolymer (X1) and osmotic agent (X2) as Independent variables that influence the drug release. PPOP tablets of metoprolol succinate were prepared by wet granulation method and evaluated for % cumulative drug release (% CDR) at 8 Hrs as dependent variable (Y). The computer optimization process, contour plots and response surface plots predicted at the concentration of independent variables X1 and X2 (45 mg, and 20 mg respectively), for maximized response. The in-vitro release kinetics studies reveal that optimized batch fits well with Korsmeyer peppas model followed by zero order, hixson crowell, first order and then higuchi’s model. Korsmeyer peppas model analysis indicated that the mechanism of drug release is non-fickian transport. An oral push-pull osmotic system that can deliver metoprolol succinate for extended period of time (12 hr) has been developed and characterized. The developed push-pull osmotic system showed the desired once a daily release kinetic....
Solubility is the major challenge concern with bioavailability. Poor aqueous solubility affects dissolution rate of drug and ultimately bioavailability. The adsorption of poor soluble drugs using porous carrier is well known technique to improve drug dissolution. The well known mesoporous material SBA-15 is 2D hexagonally ordered mesoporous silica synthesized by using non-ionic triblock co-polymer P-123 and inorganic silica precursor TEOS. Mesoporous silica attracted as drug carrier due to its adjustable and tunable pore size, high adsorption capacity, large surface area (> 900 m2/g) and large pore volume (0.9 cm3/g). The mesoporous materials are characterized by using mercury porosimetry or NO2 adsorption method, Electron microscopy to confirm the morphology of pores, PXRD to study the polymorphic changes of drug by mesoporous materials. Several in-vitro studies showing the mesoporous silica material improved the dissolution behavior of poorly soluble drugs by protecting amorphous drug from external attack or by changing crystalline state to amorphous form. Mesoporous materials provides competent drug delivery platform for poorly water soluble drugs by physiosorption and subsequent pore filling. Recently the first clinical trial of “C-dots” has deemed them safe for humans and cleared easily by the body....
Assessment of veterinary vaccine safety is often done by veterinarians in animal houses in biological units using conventional methods which is a basically a complex and time consuming. In today's era of Smart phones, tablet PCs and Notebooks where a spreadsheet program in the form of Excel is readily accessible by most veterinarians, it should be possible to adapt the various laborious steps involved in the said method to a spreadsheet program. In this article, designed a spreadsheet program based on the steps involved in conventional method for assessment of vaccine safety....
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